5/31/2023 0 Comments Pathological myopia![]() This review is to provide an updated overview of genetic findings in non-syndromic myopia. ![]() A better understanding of the genetic basis triggering and controlling myopic changes may further help in myopia prevention. Pathologic myopia (PM) is the only myopia that causes the loss of best-corrected visual acuity. In pathological myopia, certain myopia-specific pathologies occur at the eye’s posterior. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all. Myopia progression also increases the risk of getting eye diseases. Pathologic Myopia is a major cause of severe vision loss worldwide. This can affect the child’s performance both at school and in sports. ![]() In some children, myopia can progress rapidly, resulting in a worsening of vision in just a few months. The diagnosis of MTM by slit-lamp biomicroscopy was very difficult 16, 17. There exist ethnic variations in myopia occurrence as observed in populations of different genetic backgrounds, and different genetic components are found to be associated with the development of myopia-related phenotypes. Pathological myopia is also known as degenerative myopia because it ultimately leads to blindness. Pathological Myopia Detection - ‘Peripapillary atrophy detection for pathological myopia detection’ Age related Macular Degeneration Diagnosis - ‘Early AMD detection from R & D Engineer. Myopia Increases the Risk of Eye Diseases. Myopic traction maculopathy (MTM), including retinal schisis (RS) and macular hole retinal detachment (MHRD), is a pathologic myopia-related complication caused by some mechanisms with traction as a common pathway. Recent molecular technologies such as linkage analysis, candidate gene authentication, genome-wide association study (GWAS), and next-generation sequencing (NGS) have identified many myopia-associated loci and genetic mutations or variants. Myopia, particularly high myopia, often exhibits apparent familial aggregation, and multiple evidences have shown that genetic factors significantly contribute to its pathogenesis. It's a significant global public health concern in 21st century. Vision loss related to pathologic myopia is of great clinical significance as it can be progressive, irreversible and affects individuals during their most productive years. Myopia is one of the leading ocular disorders causing visual impairment worldwide, with the prevalence increasing rapidly. Pathologic myopia represents a subgroup of myopia and affects up to 3 of the world population.
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